IMGT/mAb-DB (doc) LIGM, Montpellier, France.IMGT/3Dstructure-DB and IMGT/2Dstructure-DB (doc) LIGM, Montpellier, FranceģD structures (IMGT Colliers de Perles) of IG antibodies, TR, MH and RPI.International nomenclature for IG and TR genes from 35 species IMGT/GENE-DB (doc) LIGM, Montpellier, France.IG sequences from CLL, an initiative of the IMGT/CLL-DB group IMGT/CLL-DB (bylaws) LIGM, Montpellier, France.Oligonucleotides (primers) of IG and TR from 11 species IMGT/PRIMER-DB (doc) LIGM, Montpellier, France.IMGT/MH-DB ANRI, BPRC, hosted at EBI Sequences of the human MH (HLA).Nucleotide sequences of IG and TR from 361 species IMGT/LIGM-DB (doc) LIGM, Montpellier, France.IMGT Scientific chart IMGT-ONTOLOGY IMGT Repertoire IMGT/LIGM-DB IMGT/GENE-DB IMGT reference directory IMGT/V-QUEST IMGT/HighV-QUEST IMGT/JunctionAnalysis IMGT/StatClonotype IMGT/CLL-DB IMGT/2Dstructure-DB IMGT/3Dstructure-DB IMGT/Collier-de-Perles IMGT/DomainSuperimpose IMGT/DomainGapAlign IMGT/mAb-DB I m M uno G ene T ics Information system® 2D and 3D structure databases and tools for analysis of the adaptive immune proteins and engineered antibodies and TR. Analysis and exploration of the expressed IG and TR repertoires based on comparison with IMGT reference directories in normal and pathological situations. Axis I Axis II Axis III Understanding the adaptive immune response by deciphering the immunoglobulins (IG) and T cell receptor (TR) genes on the genomic loci of jawed vertebrates. IMGT® is dedicated to advancing scientific knowledge through its three main axes of researchĪnd development. To the scientific community for in-depth exploration of the adaptive immune response. It provides databases and tools based on the IMGT-ONTOLOGY IMGT® is a pioneering international information system in immunogenetics and immunoinformatics. IMGT/V-QUEST and IMGT/HighV-QUEST are available at the IMGT(®) Home page. IMGT/HighV-QUEST, the high-throughput version of IMGT/V-QUEST, implemented to answer the needs of deep sequencing data analysis from Next Generation Sequencing (NGS), allows the analysis of thousands of IG and TR sequences in a single run. IMGT/V-QUEST integrates IMGT/JunctionAnalysis for a detailed analysis of the V-J and V-D-J junctions and IMGT/Automat for a complete annotation of the sequences and also provides IMGT Collier de Perles. The tool describes the V-REGION mutations and identifies the hot spot positions in the closest germline V gene. IMGT/V-QUEST identifies the V, D, J genes and alleles by alignment with the germline IG and TR gene and allele sequences of the IMGT reference directory. These mechanisms include the combinatorial rearrangements of the variable (V), diversity (D) and joining (J) genes, the N-diversity (deletion and addition at random of nucleotides during the V-(D)-J rearrangement) and, for IG, somatic hypermutations. This huge diversity results from mechanisms that occur at the DNA level during the IG and TR molecular synthesis. The expressed IG and TR repertoires represent a potential of 10(12) IG and 10(12) TR per individual. The analysis of these antigen receptors represents a crucial challenge for the study of the adaptive immune response in normal and disease-related situations. IMGT/V-QUEST is the highly customized and integrated online IMGT(®) tool for the standardized analysis of the immunoglobulin (IG) or antibody and T cell receptor (TR) rearranged nucleotide sequences.
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